桦树茸降血糖类功能食品研究

作者

  • 徐晟 江南大学食品学院,江南大学,无锡市214122,江苏省,中国
  • 苏瑞 无锡华跃生物科技有限公司,无锡市214126,江苏省,中国
  • 韦帅帅 江南大学食品学院,江南大学,无锡市214122,江苏省,中国
  • 章立平 无锡谷晶生物科技有限公司,无锡214126,江苏省,中国;高安市清河油脂有限公司,高安市330800,江西省,中国
  • 章文翰 无锡谷晶生物科技有限公司,无锡214126,江苏省,中国;高安市清河油脂有限公司,高安市330800,江西省,中国
  • 孙海辉 大海龟生命科技有限公司,宜春市336000,江西省,中国
  • 沈燕 江苏省食品质量安全重点实验室-省部共建国家重点实验室培育基地,江苏省农业科学院,南京市210014,江苏省,中国;公共检测评价鉴定技术中心,江苏省农业科学院,南京市210014,江苏省,中国
  • 马伟 江南大学食品学院,江南大学,无锡市214122,江苏省,中国
Ariticle ID: 187
28 Views, 4 PDF Downloads

DOI:

https://doi.org/10.18686/zhfnc.v2i3.187

关键词:

桦树茸;血糖;功能性食品;糖尿病

摘要

桦树茸又称桦褐孔菌 [Inonotus obliquus (Fr.) Pilát] 属担子菌亚门(Basidiomycotina)、层菌纲(Hymenomycetes)、锈革孔菌目(Hymenochaetales)、锈革菌科(Hymenochaetaceae)、褐卧孔菌属(纤孔菌属)(Inonotus)。桦树茸为褐色的多孔菌,多生于白桦树、银桦树等的树皮下,在树皮破损处形成肉瘤状的菌核。桦树茸的产地主要分布在北纬40°至50°的北欧、俄罗斯西伯利亚和远东、日本北海道以及中国黑龙江和吉林的长白山地区,因其具有抗肿瘤、降血糖、抗病毒、抗炎等多种药理活性作用,这种药食同源的食用真菌正日益受到人们的关注。目前,桦树茸已经成为一种极具开发潜力的功能食品原料。本文综述了桦树茸降低血糖的功能、功能成分、降血糖机理以及桦树茸功能食品的开发现状并对其未来发展做出分析与展望。

参考

Rhee SJ, Cho SY, Kim KM, et al. A comparative study of analytical methods for alkali-soluble β-glucan in medicinal mushroom, Chaga (Inonotus obliquus). LWT - Food Science and Technology. 2008; 41(3): 545-549. doi: 10.1016/j.lwt.2007.03.028

Fordjour E, Manful CF, Javed R, et al. Chaga mushroom: A super-fungus with countless facets and untapped potential. Frontiers in Pharmacology. 2023; 14. doi: 10.3389/fphar.2023.1273786

李姝宇. 桦树茸的化学成分和药理作用的研究进展. 大医生. 2017; 2(05): 66, 88. doi: 10.19604/j.cnki.dys.2017.05.039

Li S. Research progress on chemical components and pharmacological effects of Chaga (Chinese). Doctor. 2017; 2(05): 66, 88. doi: 10.19604/j.cnki.dys.2017.05.039

刘艺珠, 宋冠洁, 郭苗苗, 等.桦树茸活性成分及药理活性研究进展. 中医药导报. 2023; 29(01): 96-104. doi: 10.13862/j.cn43-1446/r.2023.01.018

Liu Y, Song G, Guo M, et al. Research progress of active ingredients and pharmacological activity of Chaga mushroom (Chinese). Guiding Journal of Traditional Chinese Medicine and Pharmacy. 2023; 29(01): 96-104. doi: 10.13862/j.cn43-1446/r.2023.01.018

W. Thomas P, Ahmed Elkhateeb W, Daba GM. Chaga (Inonotus obliquus): A medical marvel but a conservation dilemma? Sydowia—An International Journal of Mycology. 2020; (72): 123-130. doi: 10.12905/0380.sydowia72-2020-0123

张新宇, 张彦龙. 桦树茸有效成分及生物活性应用现状. 高原农业. 2018; 2(5): 549-557. doi: 10.19707/j.cnki.jpa.2018.05.015

Zhang X, Zhang Y. Application status of active ingredients and bioactivities of Betula (Chinese). Journal of Plateau Agriculture. 2018; 2(5): 549-557. doi: CNKI:SUN:GYNY.0.2018-05-015

Lindequist U, Niedermeyer THJ, Jülich WD. The pharmacological potential of mushrooms. Evidence-Based Complementary and Alternative Medicine. 2000; 2(3): 285-299. doi: 10.1093/ecam/neh107

Abu-Reidah IM, Critch AL, Manful CF, et al. Effects of pH and temperature on water under pressurized conditions in the extraction of nutraceuticals from Chaga (Inonotus obliquus) mushroom. Antioxidants. 2021; 10(8): 1322. doi: 10.3390/antiox10081322

Géry A, Dubreule C, André V, et al. Chaga (Inonotus obliquus), a future potential medicinal fungus in oncology? A chemical study and a comparison of the cytotoxicity against human lung adenocarcinoma cells (A549) and human bronchial epithelial cells (BEAS-2B). Integrative Cancer Therapies. 2018; 17(3): 832-843. doi: 10.1177/1534735418757912

Wang J, Wang C, Li S, et al. Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway. Biomedicine & Pharmacotherapy. 2017; 95: 1669-1677. doi: 10.1016/j.biopha.2017.09.104

朱明微, 苗利, 李鑫, 王柳婷. 复方桦树茸片的制备及其对糖尿病小鼠降血糖作用研究. 特产研究. 2022; 44(6): 44-49. doi: 10.16720/j.cnki.tcyj.2022.181

Zhu M, Miao L, Li X, Wang L. Preparation of compound Inonotus obliquus tablets and its hypoglycemic effect on diabetic mice (Chinese). Special Wild Economic Animal and Plant Research. 2022; 44(6): 44-49. doi: 10.16720/j.cnki.tcyj.2022.181

周秀梅, 赵静宇, 王美, 等. 药用真菌桦褐孔菌多糖的降糖实验研究. 山西医药杂志. 2019; 48(10): 1163-1166. doi: CNKI:SUN:SXYY.0.2019-10-009

Zhou X, Zhao J, Wang M, et al. Experimental study on hypoglycemic effect of polysaccharide from medicinal fungus Inonotus obliquus (Chinese). Shanxi Medical Journal. 2019; 48(10): 1163-1166. doi: CNKI:SUN:SXYY.0.2019-10-009

赵佳茜, 朱长俊, 刘兰, 等. 桦褐孔菌多糖对小鼠的降血糖研究. 生物化工. 2021; 7(4): 99-102.

Zhao J, Zhu C, Liu L, et al. Study on hypoglycemic effect of polysaccharides from Inonotus obliquus on mice (Chinese). Biological Chemical Engineering. 2021; 7(4): 99-102.

Xu X, Pang C, Yang C, et al. Antihyperglycemic and antilipidperoxidative effects of polysaccharides extracted from medicinal mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on alloxan-diabetes mice. International Journal of Medicinal Mushrooms. 2010; 12(3): 235-244. doi: 10.1615/intjmedmushr.v12.i3.20

Lu X, Chen H, Dong P, et al. Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. Journal of the Science of Food and Agriculture. 2009; 90(2): 276-280. doi: 10.1002/jsfa.3809

刘畅, 崔敬爱, 王思霁, 等. 桦褐孔菌多糖对糖尿病肾病小鼠肾脏的保护作用. 食品工业科技. 2021; 42(2): 321-325. doi: 10.13386/j.issn1002-0306.2020050108

Liu C, Cui J, Wang S, et al. Protective effect of Inonotus obliquus polysaccharides on kidneys of diabetic kidney disease mice (Chinese). Science and Technology of Food Industry. 2021; 42(2): 321-325. doi: 10.13386/j.issn1002-0306.2020050108

Feng Y, Liu J, Gong L, et al. Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway. Chinese Journal of Natural Medicines, 2024, 22(7): 619–631. doi: 10.1016/S1875-5364(24)60616-3

王聪. 桦褐孔菌中降血糖活性物质基础的研究 [博士学位论文]. 天津大学; 2018. doi: 10.27356/d.cnki.gtjdu.2018.002924

Wang C. Study on the basis of hypoglycemic active substances in Inonotus obliquus (Chinese) [PhD thesis]. Tianjin University; 2018. doi: 10.27356/d.cnki.gtjdu.2018.002924

Zhu F, Du B, Bian Z, et al. Beta-glucans from edible and medicinal mushrooms: Characteristics, physicochemical and biological activities. Journal of Food Composition and Analysis. 2015; 41: 165-173. doi: 10.1016/j.jfca.2015.01.019

Luan F, Ji Y, Peng L, et al. Extraction, purification, structural characteristics and biological properties of the polysaccharides from Codonopsis pilosula: A review. Carbohydrate Polymers. 2021; 261: 117863. doi: 10.1016/j.carbpol.2021.117863

Virgen-Carrillo CA, Martínez Moreno AG, Valdés Miramontes EH. Potential hypoglycemic effect of pomegranate juice and its mechanism of action: A systematic review. Journal of Medicinal Food. 2020; 23(1): 1-11. doi: 10.1089/jmf.2019.0069

Guo M, Shao S, Wang D, et al. Recent progress in polysaccharides from Panax ginseng C. A. Meyer. Food & Function. 2021; 12(2): 494-518. doi: 10.1039/d0fo01896a

He P, Zhang Y, Li N. The phytochemistry and pharmacology of medicinal fungi of the genus Phellinus: A review. Food & Function. 2021; 12(5): 1856-1881. doi: 10.1039/d0fo02342f

Shen J, Hu M, Tan W, et al. Traditional uses, phytochemistry, pharmacology, and toxicology of Coreopsis tinctoria Nutt.: A review. Journal of Ethnopharmacology. 2021; 269: 113690. doi: 10.1016/j.jep.2020.113690

夏晴. 桦褐孔菌体内外降血糖作用评估及其有效成分的鉴定 [硕士学位论文]. 华中农业大学; 2020. doi: 10.27158/d.cnki.ghznu.2020.001254

Xia Q. Evaluation of the hypoglycemic effect of Inonotus obliquus in vivo and in vitro and identification of its active ingredients (Chinese) [Master’s thesis]. Huazhong Agricultural University; 2020. doi: 10.27158/d.cnki.ghznu.2020.001254

邵珠领, 张宇, 万国靖, 等. 以桦褐孔菌为主的复合多糖降糖活性研究. 广东化工. 2017; 44(16): 14-15. doi:CNKI:SUN:GDHG.0.2017-16-007

Shao Z, Zhang Y, Wan G, et al. Study on the hypoglycemic activity of complex polysaccharides based on Inonotus obliquus (Chinese). Guangdong Chemical Industry. 2017; 44(16): 14-15. doi: CNKI:SUN:GDHG.0.2017-16-007

Ye X, Wu K, Xu L, et al. Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora. Frontiers in Endocrinology. 2023; 13. doi: 10.3389/fendo.2022.1103972

Wang S, Wang R, Li R, et al. Research progress on application of Inonotus obliquus in diabetic kidney disease. Journal of Inflammation Research. 2023; 16: 6349-6359. doi: 10.2147/jir.s431913

Zhang Y, Liao H, Shen D, et al. Renal protective effects of Inonotus obliquus on high-fat diet/streptozotocin-induced diabetic kidney disease rats: Biochemical, color Doppler ultrasound and histopathological evidence. Frontiers in Pharmacology. 2022; 12. doi: 10.3389/fphar.2021.743931

Chou YJ, Kan WC, Chang CM, et al. Renal protective effects of low molecular weight of Inonotus obliquus polysaccharide (LIOP) on HFD/STZ-induced nephropathy in mice. International Journal of Molecular Sciences. 2016; 17(9): 1535. doi: 10.3390/ijms17091535

Wang C, Gao X, Santhanam RK, et al. Effects of polysaccharides from Inonotus obliquus and its chromium (III) complex on advanced glycation end-products formation, α-amylase, α-glucosidase activity and H2O2-induced oxidative damage in hepatic L02 cells. Food and Chemical Toxicology. 2018; 116: 335-345. doi: 10.1016/j.fct.2018.04.047

Wang C, Chen Z, Pan Y, et al. Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice. Food and Chemical Toxicology. 2017; 108: 498-509. doi: 10.1016/j.fct.2017.01.007

Sun J, Xu H, Ao Z, et al. Study on the hypoglycemic effect of Inonotus obliquus and Tricholoma matsutake powder (Chinese). Natural Product Research and Development. 2009; 21(2): 339-342. doi: 10.16333/j.1001-6880.2009.02.040

孙军恩, 许泓瑜, 敖宗华, 等. 桦褐孔菌与松口蘑菌粉降血糖作用的研究. 天然产物研究与开发. 2009; 21(2): 339-342. doi: 10.16333/j.1001-6880.2009.02.040

Sun J, Xu H, Ao Z, et al. Study on the hypoglycemic effect of Inonotus obliquus and Tricholoma matsutake powder (Chinese). Natural Product Research and Development. 2009; 21(2): 339-342. doi: 10.16333/j.1001-6880.2009.02.040

Das AK, Nanda PK, Dandapat P, et al. Edible mushrooms as functional ingredients for development of healthier and more sustainable muscle foods: A flexitarian approach. Molecules. 2021; 26(9): 2463. doi: 10.3390/molecules26092463

Sharpe E, Farragher-Gnadt AP, Igbanugo M, et al. Comparison of antioxidant activity and extraction techniques for commercially and laboratory prepared extracts from six mushroom species. Journal of Agriculture and Food Research. 2021; 4: 100130. doi: 10.1016/j.jafr.2021.100130

裴河欢, 张美凤, 覃洋琛, 等. 多酚类化合物药理作用研究进展. 中国药业. 2022; 31(23): 124-127. doi: 10.3969/j.issn.1006 -4931.2022.23.030

Pei H, Zhang M, Qin Y, et al. Research progress on pharmacological effects of polyphenols (Chinese). China Pharmaceuticals. 2022; 31(23): 124-127. doi: 10.3969/j.issn.1006 -4931.2022.23.030

董琦, 高珊, 曹龙奎. 大孔树脂纯化桦褐孔菌多酚及其成分分析. 食品科学. 2015; 36(22): 131-136. doi: 10.7506/spkx1002-6630-201522024

Dong Q, Gao S, Cao L. Purification of polyphenols from Inonotus obliquus by macroporous resin and analysis of its components (Chinese). Food Science. 2015; 36(22): 131-136. doi: 10.7506/spkx1002-6630-201522024

朱金卫, 徐向群. 桦褐孔菌多酚的液体深层制备及抗氧化活性研究. 浙江理工大学学报. 2011; 28(4): 616-620. doi: 10.3969/j.issn.1673-3851.2011.04.028

Zhu J, Xu X. Liquid deep preparation and antioxidant activity of Inonotus obliquus polyphenols (Chinese). Journal of Zhejiang Sci-Tech University. 2011; 28(4): 616-620. doi: 10.3969/j.issn.1673-3851.2011.04.028

Nakajima Y, Sato Y, Konishi T. Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga). Chemical and Pharmaceutical Bulletin. 2007; 55(8): 1222-1226. doi: 10.1248/cpb.55.1222

Peng H, Shahidi F. Qualitative analysis of secondary metabolites of chaga mushroom (Inonotus obliquus): Phenolics, fatty acids, and terpenoids. Journal of Food Bioactives. 2022; 17: 56–72. doi: 10.31665/jfb.2022.17304

Iwai K. Antidiabetic and antioxidant effects of polyphenols in brown alga Ecklonia stolonifera in genetically diabetic KK-Ay mice. Plant Foods for Human Nutrition. 2008; 63(4): 163-169. doi: 10.1007/s11130-008-0098-4

Tadera K, Minami Y, Takamatsu K, et al. Inhibition of α-glucosidase and α-amylase by flavonoids. Journal of Nutritional Science and Vitaminology. 2006; 52(2): 149-153. doi: 10.3177/jnsv.52.149

Prabhakar PK, Doble M. Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine. 2009; 16(12): 1119-1126. doi: 10.1016/j.phymed.2009.05.021

武建平, 李文兰, 曲中原, 等. 基于网络药理学探讨桦褐孔菌降血糖功效成分及作用机制. 食品工业科技. 2021; 42(22): 18-29. doi: 10.13386/j.issn1002-0306.2021040268

Wu J, Li W, Qu Z, et al. Action mechanism of Inonotus obliquus in the treatment of diabetes and the material basis of pharmacodynamics based on network pharmacology (Chinese). Science and Technology of Food Industry. 2021; 42(22): 18-29. doi: 10.13386/j.issn1002-0306.2021040268

刘艺珠, 宋冠洁, 郭苗苗, 等. 桦树茸活性成分及药理活性研究进展. 中医药导报. 2023; 29(1): 96-104. doi: 10.13862/j.cn43-1446/r.2023.01.018

Liu Y, Song G, Guo M, et al. Research progress of active ingredients and pharmacological activity of Chaga mushroom (Chinese). Guiding Journal of Traditional Chinese Medicine and Pharmacology. 2023; 29(1): 96-104. doi: 10.13862/j.cn43-1446/r.2023.01.018

黄盼盼, 陈程, 徐向群. 桦褐孔菌三萜对α-葡萄糖苷酶和α-淀粉酶的抑制活性及其有效成分鉴定. 浙江理工大学学报(自然科学版). 2020; 43(5): 678-686. doi: 10.3969/j.issn.1673-3851(n).2020.05.013

Huang P, Chen C, Xu X. Inhibitory activity of triterpenoids from Inonotus obliquus on α-glucosidase and α-amylase and identification of their effective compounds (Chinese). Journal of Zhejiang Sci-Tech University. 2020; 43(5): 678-686. doi: 10.3969/j.issn.1673-3851(n).2020.05.013

Wang S, Wang R, Li R, et al. Research progress on application of Inonotus obliquus in diabetic kidney disease. Journal of Inflammation Research. 2023; Volume 16: 6349-6359. doi: 10.2147/jir.s431913

Singla RK, Singh R, Dubey AK. Important aspects of post-prandial antidiabetic drug, acarbose. Current Topics in Medicinal Chemistry. 2016; 16(23): 2625-2633. doi: 10.2174/1568026616666160414123500

杨珺尧, 孟利. 桦褐孔菌及其药理作用研究进展. 食药用菌. 2021; 29(3): 202-207. doi: 2095-0934(2021)03-202-06

Yang J, Meng L. Research progress on Inonotus obliquus and its pharmacological effects (Chinese). Edible and Medicinal Mushrooms. 2021; 29(3): 202-207. doi: 2095-0934(2021)03-202-06

杜文婧, 王琦. 桦褐孔菌资源分布及药理活性研究进展. 菌物研究. 2013; 11(1): 49-56. doi: 10.13341/j.jfr.2013.01.008

Du W, Wang Q. A review of the distribution and pharmacological activity of Inonotus obliquus (Chinese). Journal of Fungal Research. 2013; 11(1): 49-56. doi: 10.13341/j.jfr.2013.01.008

李艳婷, 郭尚, 徐莉娜, 等. 桦褐孔菌资源分布及其地域环境条件分析. 中国林副特产. 2019; 4: 60-65. doi: 10.13268/j.cnki.fbsic.2019.04.024

Li Y, Guo S, Xu L, et al. Study on review of the distribution and environmental conditions of Inonotus obliquus (Chinese). Forest By-Product and Speciality in China. 2019; 4: 60-65. doi: 10.13268/j.cnki.fbsic.2019.04.024

Sułkowska-Ziaja K, Robak J, Szczepkowski A, et al. Comparison of bioactive secondary metabolites and cytotoxicity of extracts from Inonotus obliquus isolates from different host species. Molecules. 2023; 28(13): 4907. doi: 10.3390/molecules28134907

Zheng W, Zhang M, Zhao Y, et al. Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus. Bioresource Technology. 2009; 100(3): 1327-1335. doi: 10.1016/j.biortech.2008.05.002

Xue J, Tong S, Wang Z, et al. Chemical Characterization and hypoglycaemic activities in vitro of two polysaccharides from Inonotus obliquus by submerged culture. Molecules. 2018; 23(12): 3261. doi: 10.3390/molecules23123261

Jarosz A, Skórska M, Rzymowska J, et al. Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells. Acta Biochimica Polonica. 1990; 37(1): 149-151. doi: 10.1016/0005-2728(90)90227-U

姜志波. 桦褐孔菌的液体发酵培养及其生物活性物质的研究 [硕士学位论文]. 大连工业大学; 2016. doi:CNKI:CDMD:2.1016.285339

Jiang Z. Study on liquid fermentation culture of Inonotus obliquus and its bioactive substances (Chinese) [Master’s thesis]. Dalian Polytechnic University; 2016. doi: CNKI:CDMD:2.1016.285339

Xu X, Li J, Hu Y. Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterization. International Immunopharmacology. 2014; 21(2): 269-278. doi: 10.1016/j.intimp.2014.05.015

闫舒雅, 郭素萍. 桦褐孔菌发酵条件的优化及体外降糖作用的研究. 安徽农业科学. 2021; 49(19): 157-160. doi:10.3969/j.issn.0517-6611.2021.19.041

Yan S, Guo S. Optimization of fermentation conditions of Inonotus obliquus and research on hypoglycemic in vitro (Chinese). Journal of Anhui Agricultural Sciences. 2021; 49(19): 157-160. doi: 10.3969/j.issn.0517-6611.2021.19.041

陈盛宇, 田缘, 马俊秀, 等. 桦褐孔菌多糖研究现状与展望. 食品研究与开发. 2022; 43(22): 215-224. doi:10.12161/j.issn.1005-6521.2022.22.030

Chen S, Tian Y, Ma J, et al. Current status and prospects of research on polysaccharides from Inonotus obliquus (Chinese). Food Research & Development. 2022; 43(22): 215-224. doi: 10.12161/j.issn.1005-6521.2022.22.030

Lou H, Li H, Wei T, et al. Stimulatory effects of oleci acid and fungal elicitor on betulinic acid production by submerged cultivation of medicinal mushroom inonotus obliquus. Journal of Fungi. 2021; 7(4): 266. doi: 10.3390/jof7040266

Xu X, Hu Y, Quan L. Production of bioactive polysaccharides by Inonotus obliquus under submerged fermentation supplemented with lignocellulosic biomass and their antioxidant activity. Bioprocess and Biosystems Engineering. 2014; 37(12): 2483-2492. doi: 10.1007/s00449-014-1226-1

Abu-Reidah IM, Critch AL, Manful CF, et al. Effects of pH and temperature on water under pressurized conditions in the extraction of nutraceuticals from Chaga (Inonotus obliquus) mushroom. Antioxidants. 2021; 10(8): 1322. doi: 10.3390/antiox10081322

Huynh N, Beltrame G, Tarvainen M, et al. Supercritical CO2 extraction of triterpenoids from Chaga sterile conk of Inonotus obliquus. Molecules. 2022; 27(6): 1880. doi: 10.3390/molecules27061880

陈正启, 周汐, 华蓉, 等. 桦褐孔菌的研究现状及应用前景. 中国食用菌. 2021; 40(10): 1-6. doi: 10.13629/j.cnki.53-1054.2021.10.001

Chen Z, Zhou X, Hua R, et al. Research status and application prospects of Inonotus obliquus (Chinese). Edible Fungi of China. 2021; 40(10): 1-6. doi: 10.13629/j.cnki.53-1054.2021.10.001

Lu Y, Jia Y, Xue Z, et al. Recent Developments in Inonotus obliquus (Chaga mushroom) polysaccharides: Isolation, structural characteristics, biological activities and application. Polymers. 2021; 13(9): 1441. doi: 10.3390/polym13091441

Shashkina MYa, Shashkin PN, Sergeev AV. Chemical and medicobiological properties of Chaga (review). Pharmaceutical Chemistry Journal. 2006; 40(10): 560-568. doi: 10.1007/s11094-006-0194-4

王磊鑫, 孙涛, 甄翔, 等. 桦褐孔菌乳酸菌饮料的研制. 食品科技. 2009; 34(9): 101-103. doi: CNKI:SUN:SSPJ.0.2009-09-030

Wang L, Sun T, Zhen X, et al. Study on Inonotus obliquus lactic acid bacteria beverage (Chinese). Food Science and Technology. 2009; 34(9): 101-103. doi: CNKI:SUN:SSPJ.0.2009-09-030

Chen H, Liou B, Hsu K, et al. Implementation of food safety management systems that meets ISO 22000: 2018 and HACCP: A case study of capsule biotechnology products of chaga mushroom. Journal of Food Science. 2020; 86(1): 40-54. doi: 10.1111/1750-3841.15553

Alkhatib A, Klonizakis M. Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women. Clinical Hemorheology and Microcirculation. 2014; 57(1): 33-47. doi: 10.3233/ch-131770

Middleton G, Keegan R, Smith MF, et al. Implementing a Mediterranean diet intervention into a RCT: Lessons learned from a non-Mediterranean based country. The Journal of Nutrition, Health & Aging. 2015; 19(10): 1019-1022. doi: 10.1007/s12603-015-0663-0

Martínez-González MA. Benefits of the Mediterranean diet beyond the Mediterranean Sea and beyond food patterns. BMC Medicine. 2016; 14(1). doi: 10.1186/s12916-016-0714-3

Topolska K, Florkiewicz A, Filipiak-Florkiewicz A. Functional food—Consumer motivations and expectations. International Journal of Environmental Research and Public Health. 2021; 18(10): 5327. doi: 10.3390/ijerph18105327

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2024-09-23

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徐晟, 苏瑞, 韦帅帅, 章立平, 章文翰, 孙海辉, 沈燕, & 马伟. (2024). 桦树茸降血糖类功能食品研究. 食品营养化学, 2(3), 187. https://doi.org/10.18686/zhfnc.v2i3.187

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